07-P019 Small molecule screening of zebrafish models of disease and development

نویسندگان

  • Caroline Parkin
  • Sarah Baxendale
  • Susan Smith
  • Marysia Placzek
چکیده

embryogenesis. We extended this analysis to other Hox-Exd, or Hox-Hox interactions, revealing specific spatial and temporal dynamics during embryogenesis. Altogether, these results show that the BiFC is a highly sensitive method for analysing protein– protein interactions in the living drosophila embryo. Based on the BiFC approach, we established two genetic strategies to find novel cofactors of AbdA. Our preliminary results suggest that Hox proteins are able to interact with many different types of transcription factors, and we will present some of them to illustrate this point.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Small molecule screening in the zebrafish.

The zebrafish is an ideal organism for small molecule studies. The ability to use the whole organism allows complex in vivo phenotypes to be assayed and combines animal testing with screening. Embryos are easily treatable by waterborne exposure. The small size and abundance of embryos make zebrafish suitable for screening in a high-throughput manner in 96- or 48-well plates. Zebrafish embryos h...

متن کامل

ScreenCube: A 3D Printed System for Rapid and Cost-Effective Chemical Screening in Adult Zebrafish.

Phenotype-based small molecule screens in zebrafish embryos and larvae have been successful in accelerating pathway and therapeutic discovery for diverse biological processes. Yet, the application of chemical screens to adult physiologies has been relatively limited due to additional demands on cost, space, and labor associated with screens in adult animals. In this study, we present a 3D print...

متن کامل

The recent development in synthesis and pharmacological evaluation of small molecule to treat Alzheimer's diseases: A review

Alzheimer's disease is a neurological disorder in which the death of brain cells causes memory loss and cognitive decline. A neurodegenerative type of dementia, the disease starts mild and gets progressively worse. Like all types of dementia, Alzheimer's is caused by brain cell death. The most common presentation marking Alzheimer's dementia is where symptoms of memory loss are the most promine...

متن کامل

The recent development in synthesis and pharmacological evaluation of small molecule to treat Alzheimer's diseases: A review

Alzheimer's disease is a neurological disorder in which the death of brain cells causes memory loss and cognitive decline. A neurodegenerative type of dementia, the disease starts mild and gets progressively worse. Like all types of dementia, Alzheimer's is caused by brain cell death. The most common presentation marking Alzheimer's dementia is where symptoms of memory loss are the most promine...

متن کامل

Review of the Ethical and Technical Principles of Working with Zebrafish as a Species of the Biological Model in Medical Science Studies

The Zebrafish is a preeminent model organism that, with its most prominent features, has expanded the boundaries of science in many disciplines. Characteristics of this small freshwater fish, with the help of biologists, showed that it has a highly comparable genetic with mammals such as mice and rats. For example, the emergence of new and efficient methods for duplicating and editing the genom...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Mechanisms of Development

دوره 126  شماره 

صفحات  -

تاریخ انتشار 2009